The WADA commission has directly accused the Russian government of complicity in the widespread doping and cover-ups exposed in a damning 323-page report.
It says its 11-month probe hasn't found written evidence of government involvement.
But it says "it would be naive in the extreme to conclude that activities on the scale discovered could have occurred without the explicit or tacit approval of Russian governmental authorities."
While its report largely focuses on doping in Russian athletics, it adds "there is no reason to believe that athletics is the only sport in Russia to have been affected."
WADA's independent commission says Russia's athletics federation should be suspended and its track and field athletes banned from competition until the country cleans up its act on doping.
The commission recommends that the World Anti-Doping Agency immediately declare the Russian federation "non-compliant" with the global anti-doping code, and that the IAAF suspend the federation from competition.
The report recommends that the International Olympic Committee not accept any entries from the Russian federation until the body has been declared complaint with the code and the suspension has been lifted.
Such a decision could keep Russian athletes out of next year's Olympics in Rio de Janeiro.
The WADA commission says Russian Sports Ministry Vitaly Mutko issued direct orders to "manipulate particular samples."
Mutko denied wrongdoing to the WADA inquiry panel, including knowledge of athletes being blackmailed and FSB intelligence agents interfering in lab work.
Mutko, who is also a FIFA executive committee member and leads the 2018 World Cup organizing committee, was interviewed by the WADA panel at the Baur au Lac hotel in Zurich on Sept. 22.
His ministry is cited in the report for asserting undue influence over the Moscow lab.
The commission looking into widespread doping in Russian athletics has recommended lifetime bans for five Russian middle-distance runners and five Russian coaches and administrators.
The commission said that the London Olympics were more or less sabotaged by allowing Russian athletes to compete when they should have been suspended for doping violations.
They blamed what they called an inexplicable laissez-faire attitude toward anti-doping by the IAAF and the Russian Anti-Doping Agency.
The gold and bronze-medal winners at 800 meters at the London Olympics are among the five Russian runners targeted for lifetime bans by an independent commission tasked with investigating widespread doping in that country.
The commission recommended lifetime bans for Olympic champion Mariya Savinova-Farnosova and bronze medalist Ekaterina Poistogova.
The WADA report says Moscow testing laboratory director Grigory Rodchenko ordered 1,417 doping control samples destroyed to deny evidence for the inquiry.
The inquiry report says Rodchenko "personally instructed and authorized" the destruction of evidence three days before a WADA audit team arrived in Moscow last December.
The WADA panel says it wanted to send the Russian athletes' samples to labs in other countries to detect banned drugs and doping methods.
The report says Rodchenko's action "obliterated forever the attempt to determine if there was any evidence of athletes having clean and dirty 'A' samples at the Moscow laboratory."
When the auditors arrived in Moscow, Rodchenko told them he decided to "do some clean up to prepare for WADA's visit."
Rodchenkov, the report notes, "remained obstructive" throughout the investigation and refused to be recorded.
The WADA commission wants the agency to strip accreditation from the Moscow laboratory and fire lab director Grigory Rodchenko.
The report says the "Moscow laboratory is unable to act independently," citing interference from government agencies, including the FSB secret service.
The report says Rodchenko is "an aider and abettor of the doping activities" and "at the heart of the positive drug test cover-up."
Rodchenko was key to "the conspiracy to extort money from athletes in order to cover up positive doping test results."
The WADA commission suspects Russia has been using an obscure laboratory on the outskirts of Moscow to help cover up widespread doping, possibly by pre-screening athletes' doping samples and ditching those that test positive.
It says whistleblowers and confidential witnesses "corroborated that this second laboratory is involved in the destruction and the cover-up of what would otherwise be positive doping tests."
It says the "Laboratory of the Moscow Committee of Sport for Identification for Prohibited Substances in Athlete Samples" is controlled by the Moscow city government and operates in an industrial zone about 10 kilometers (6 miles) from the city center.
The AP updates its finding from the report here: http://bigstory.ap.org/8e4ac8f10f974df79dd490e7422f4855
The full report from the WADA is available here: https://wada-main-prod.s3.amazonaws.com/resources/files/wada_independent_commission_report_1_en.pdf