I get the feeling confusing 2.2 with 2.3 is gonna be this topics "DISABLE IN-GAME ANTI ALIASING"
You forgot to change the internal resolution in Dsfix.ini. It's currently just upscaling from 720 it looks like. So no, it'll look so much better
Relevant ini values:
# internal rendering resolution of the game
# higher values will decrease performance
renderWidth 1920
renderHeight 1080
# The display width/height
# 0 means use the same resolution as renderWidth/Height
# (use for downscaling - if in doubt, leave at 0)
presentWidth 1920
presentHeight 1080
Since your picture is in 1080p just go ahead and copy the values. You can also use multiples of the 1920x1080 resolution to downsample from a higher resolution. That's the main reason DSFix was made in the first place, to allow for higher resolutions than the console versions

.