Aye. Though I have heard someone argue that having a bigger ring on the front makes a difference, no matter the ratio... but they were never able to explain it well enough for me to believe them.
There is a slight difference due to the (slightly) increased mechanical efficiency due to a large ring (fulcrum point on the crank arm is in a better position with a big ring opposed to a smaller ring), but it's very small, much of it is probably psychological, the same can be levelled at different length crank arms too (that's a whole other can'o worms).
In theory, use the largest chainring you can get away thing for the greatest mechanical effieceny, and let's not muddy the waters further with Osy rings!