Isz Root Chalice cleared. Luckily Rom wasn't there, instead the bosses were Keeper of the Old Lords, Brainsucker, and Celestial Emissary. Got a better Great Deep Sea rune, with +150 resistance for everything, and +300 frenzy resistance rune from there, but no Lost Threaded Cane, +5% DMG reduction rune, or better physical attack gems. =/ I may have to try the Sinister Isz Root Chalice the next time.
I came upon the hardest chalice room so far, with Keeper of the Old Lords accompanied by two hounds, a werewolf, and two witches throwing fire and bolt projectiles, which killed me with two hits. Died three times there.
EDIT: Forgot, that I found a Blood Rock there as well. Now I'm wondering should I max the +9 Saw Cleaver or Burial Blade to accompany the other +10 weapons I have, Cane, Ludwig, and Evelyn.