Ghostbusters 2016 has many problems, all female leads wasn't one of them(it might have deterred some idiots). Blaming the failure on budget is some false equivalency too.
A full on Ghostbusters remake just won't crush the buildings like the surprise success of the first. If it was a sequel/soft reboot thing it would have done better, but still not even Deadpool numbers IMO. As for budget, well what did you expect? A high budget makes sense considering how effects heavy a movie like Ghostbusters would be. Not to mention that the effects in the original are fondly remembered.
Where the problem lies is in a lot of factors, the audience being tired of remakes of beloved movies, the Ghostbusters franchise not holding that much weight, over saturation of Melissa McCarthy and Bridesmaids esque movies, the movie somehow becoming the most politically divisive movie of the year, lukewarm reception to trailers and footage, etc.
It was going to bomb, in retrospect it's actually pretty clear. It not due to MRA's, or because of picking the wrong budget. It's because most audiences never wanted this movie.