I've probably spent around 30 hours over the last few days on my first city, still looks like shit, there's several areas with traffic issues, got fed up with the default elementary and high schools, fire, crematorium and garbage services and ended up modding/downloading modded assets to handle it. On the garbage and crematorium front it didn't help a ton since the AI for the hearses/trucks is close to non-existent, I really hope that in a future update CO at the very least allows us to set services to only work in/for a designated district if we choose to.
Anyway roughly doubled my population in the last couple days, fighting off death waves and the population bouncing back and unlocked my ninth tile along with the OP Fusion Plant. Also demolished one of my early industrial areas but still haven't decided what I'm going to do with the area. Also have over seven million in the coffers so I can afford to do a major revamp which I'm probably going to have to do in some areas, my large snaking road commercial/office district didn't pan out the way I hoped it would and was forced to add intersections in spots to shorten travel times and the traffic was pretty brutal in that area and not enough people are using the metro lines I have set up. Don't know if I actually need to add more or place the ones I already have differently. Also still need to redo all my route lines because I'm sure they'd be better off shorter and then just have spots where stops link so Cims can move from one trains/bus to another, which I already do but in a very messy fashion. I also probably have too many train depots for loading/off-loading cargo. I'm pretty sure I have at least three I could disable.
If you don't care about vanilla assets here's a few good curated collections with a good mix
Growable Starter Pack:
http://steamcommunity.com/sharedfiles/filedetails/?id=417950430
Holy crap that seems like a lot, how much does that increase loading times and increase memory usage? I'm tempted to download all of them.
EDIT: And that 81 tiles mod... Sweet Jeebus. If you can increase the number of cims being simmed at any one time the game's is still going to be a potential resource monster for years.