Finished my first game. Really really enjoy the changes.
Rome
King difficulty
Standard Length & Map
Islands Plates
Being on my own small island really helped with curbing the barbarian onslaught as well as putting a major gulf between me and any angry civ. Was able to fit two cities there with some room to grow and was later able to expand to a nearby by island to eventually establish 3 more cities with a good bit more space.
I really was not focused on what I wanted to do for most of the early game. Didn't want to go into religion, didn't want to go culture or science. Really only focused on making a lot of gold. By mid game I was doing OK, but not great, 3-4 civs were ahead of me in every category and none of my cities had any important resources or good amounts of luxuries. But I focused heavily on maximizing my trading and gold intake. I always had a good 4k+ to play with, which helped a lot in buying improvements for districts, getting builders to help maximize my land use and keep my cities growing as much as possible so I could expand on them more.
By turn 250 or so I started to gain in culture and was keeping up with science for the most part, only 2-3 techs behind the leader for the most part. At that point I focused heavily on Tourism. I literally bought half of my great works from the US. But also created my own and lead in Great Wonders which helped. At that point I started investing in Theater Districts and archaeology which helped a great deal. I think I had 4 fully stocked museums 2 of which were themed. By turn 486 I had won, so just barely made it under the wire.
Still have a lot to learn, but there's so much more thinking involved with this at every turn. By the late game it was really becoming apparent how far head you have to think about your districts. My first to cities being on a relatively small island mean I didn't have much room between districts and wonders, plus needing certain tile improvements to maintain food and production. So there were certainly some districts I wish I hadn't build there or had done so in another location even if it had a smaller bonus or none at all.