Tips to beat Dead Space 2 Hardcore:
* Take the following weapons: Plasma Cutter - for small enemies, Infectors, and those blooming Necro plants in zero-G, Force Gun (Zealot if you have it, if you don't, put upgrades on this baby for at least 5 nodes) - useful for everything but Brutes, Pulse riffles - for necro kids and babies, and Contact Beam (upgrade all the way to its SPEC node) - will freeze and destroy anything in the radius of your path).
* Do not bother buying ammo for any weapon other than Force Gun. Do buy a lot of Force Gun ammo (15 x 2 slots every chapter at least) and spend the rest of the money on nodes and health.
* Towards the end of Chapter 2 inside the train station, you'll save yourself from a heart attack, stress, and time-wasting by stomping/dismembering the 5 dead bodies on the station. If you do, all you have to fight is 1 Infector + 1 Dark Slasher and later on after you dispatch the two 1 normal Slasher. If you don't, prepare to fight at least 2 more Dark Slashers on top of the 1 that comes out of the train.
* After you jump to the 2nd train car, immediately blow up the Exploder so it'll kill everything behind him. Then quickly turn around and move backwards while pointing a weapon/stasis object towards the open door. You'll see a Slasher crawling from a window. Give him a blowjob from the Force Gun.
* When you're hanging upside down from the train like Clarke Pinata, the Force Gun (especially Zealot) is the most efficient way of dispatching the enemies below. After they all die, quickly switch to Plasma Cutter and cut the LEFT area (your side not the Brute's actual left arm) of the Brute's body up above. It's best to position your Cutter vertically.
* During the 1st gangbang scene on the entrance of the Church (where everything will be locked), immediately run to the area where an infector can be seen trying to spread its joyful seeds to a dead body. Stasis him then kill him with Plasma Cutter. Make sure he's dead (you can tell if you see him dropping an item) then RUN! Don't bother getting the item dropped by the infector. Just run towards the stage on the elevated platform and stands on the left hand area. If you're good, you can kill the two pukers from this angle by decapitating their heads/arms. If not, don't worry, just blow them away with Force Gun when they try to approach the stairs. Pay attention to the Exploder coming from your front and later your side. After they're all dead, there'll be one lone Infector trying to have its way with you but you need to be firm and tell it that NO means NO and put an end to that sucker.
* The slamming door inside the Church (the one you need to stasis) can kill Isaac if you don't time your stasis correctly.
* The giant thing that attacks Isaac with its tentacle can be incapacitated by aiming your plasma cutter TWICE on the TOP area and TWICE on the LEFT TOP area. That's where the weak points always idly stands.
* The tormentor's weak side will always be located TWICE on RIGHT area then TWICE on LEFT area. After you do this, DO NOT PANIC when trying to kinesis the door open. Otherwise, you'll mess it up and the Tormentor will catch up with you.
* In chapter 7, ALWAYS shoot the decompression window first when you're still inside another room (the one with all of the lasers). If you do that, you can shoot the safety button from the safety of the other room without getting sucked into the window. Then just bring a body with you and slam it to the lasers when it gets activated and immediately run to the door in front of you and deal with the babies/crawlers from there.
* You can just run around in circles at the end of Chapter 7 when all of the Necros break into the room if you want to preserve ammo. Just watch out where the Necros are coming out especially the puker since it can slow you down. Then when Ellie tells you to run to the CEC door, sprint for your life there.
* In chapter 9, there are 2 ways of dealing with the decompression window. The first is to run to the left hand area (the one without the power node box) and stand way way back and shoot the window yourself. Then when you get sucked, shoot the safety. Warning: sometimes the location of your pointer is not obvious by doing it this way but you have more time to shoot the safety button. The other way is to shoot the window while you're inside the lift. It's far more dangerous because you're closer to the window but your weapon's pointer for some reason is far closer to the safety latch so it's your choice.
* Chapter 13's redrooms. In the first room, just shoot the 3 babies with plasma/riffles then walk to the right hand side and when the first Necro pops out of the vent, use Contact Beam's alt to freeze him and the other Necros. Keep running near the door and deal with the rest of the enemies from there. A combination of Force Gun + Contact Beam is necessary here. My rec is to finish what you have here before moving to the hallway because otherwise, they'll follow you through the vent. In the 2nd room, you can just run and shoot the exploder then run to the hallway and all the way to the Brute's room. They won't follow you once you get inside the Brute's room.
* Chapter 14/15. What can I say? Contact Beam's alt'd / Stasis'd / Force Gun'd / Run your way through these two levels.
* Last flying sequence. It's best to follow the ship for direction. But on the 2nd debris, make sure you stay in the middle until you see the next debris then steer immediately to right to avoid both debris.