Yep this.
Apart from that it also does not make sense that you'd progress a storyline if you never start it, that's how it was in DE1 too. You could say that the game can avoid this by preventing you from killing quest givers or limiting an interaction so that you always end up having a conversation with a quest giver rather than going through them, but that's not what Deus Ex is about. Outside of the really key characters everyone is killable, which is actually less than what you could in DE1 where you could even kill the key guys.
I dont go around killing everybody, only on missions or thugs trying to stop me from doing something, but could I just kill a shop keeper, like the drug dealer next door? If I kill him I can no long buy from him.