I've been thinking about this lately, and tried it a few pub games and so far have been impressed with the results.
Tinker
I had still been trying to roll with the traditional Tinker skill build even since the nerf: 1-2-4-1 by 8. Since the march nerf, this isn't really enough to make you have an impact on the game. The meta has changed more where mids are more farming and scaling to lategame, you still can't just be a liability for 10-15 minutes.
I've been trying 4-4-0-1 by 9. I have had a ton more success with this build, and usually gotten BoTs before 10 minutes with no problems. This build allows you to participate much more in fights, and hell even blow up most of the mids that are popular right now. The common concern with this build in the past was that if you felt behind, you needed March to jungle or ancients to catch up. You can catch up by rotating to fights and finding lanes to farm when you can if you somehow fall behind, but right now with this build, it's much harder to fall behind anyway. If you do you can still catch up. Even if you need to take one value point in March, you can still march stacks of jungle camps with one point in March.
Beyond that, I think Aghs centric builds are the thing. With a 0.75 second rearm, 4 missiles and refracting laser are huge right now. March is not anywhere near as good as it used to be. Standing in a lot of them hurts, but not quite as much as it did when it was mixed damage. After BoTs and Soul Ring, I like to go Blink -> Aghs -> BoTs 2 > Bloodstone > Shiva's > Whatever else you might need. BoTs 2 also really helps when you have Aghs.
