Re-installed New Vegas after reading zkylon's mod recommendations (thank you, sir). I must have spent a good few hours figuring out how to get things up and running. Thought I was out of luck for a moment there because of complications with ArchiveInvalidated, but then found a file that I must have backed up the last time I tried doing this that did the trick.
By the time I'd finished downloading, installing and configuring the mods, it was well past my regular bed time. I managed to create a character and run around the starting area. Looking forward to going through the game again as I've only beaten it once (non-hardcore) and have yet to try out the DLC (only Dead Money & Honest Hearts, won't get the other two until they're ~$1 apiece).
Some early feedback on the mods I'm using:
FNV Shaders
I believe I was running the "light" version before, and I couldn't tell the difference, so I tried the full "Delta F" version this time around, which looks noticeably better. Highly recommended.
Nevada Skies
Running vanilla and loving it. More subdued, realistic hue to the skies. Highly recommended.
Weapon Animation Replacers
This is a must-have for me. I absolutely loathed the default, gun-in-everyone's-face stance. This mod offers several idle animation choices for both rifles and pistols in both first and third-person perspective. As someone who switches between 3rd and 1st person perspective often, this makes a world of a difference for immersion even though it's a really minor touch. My character no longer looks as though she's ready to shoot anything on sight.
I downloaded Fallout Redesigned but couldn't get around the ArchiveInvalidated stuff, so I moved onto other mods. By the time I'd realized I had a working ArchiveInvalidated patcher, I had already installed body and face mods, so now I'm afraid to install it due to possible compatibility issues. I really like the work he's done, however, so maybe I'll risk it.