I've not gotten through a few games this year yet but I'll go with what I have:
1. Gears of War 2
2. No More Heroes
3. Fallout 3
4. Final Fantasy IV
5. Fable 2
6. PES 2009
7. LittleBigPlanet
8. Castlevania: Order of Ecclesia
9. Bangai-O Spirits
10. Boom Blox
I've not played Resistance 2 yet (I do own it) - I've just got my PS3 and I'm playing through the first one at the minute - I'm enjoying that a lot so the sequel would likely make my list unless it's gone radically backwards.
I've also not played MGS4, NG2, Dead Space, DMC4, GTA4 (own), World of Goo, de Blob, Wario Land, etc and these all look like games I'd enjoy and would possibly crack this list at some level.
edit: forgot Left 4 Dead. Only played the demo (which I loved). I reckon that this, MGS4, Resistance 2, Dead Space would all be certain to crack my top 10. Oh man, forgot Mother 3. I have it ready to go, that would make it as well.
edit2: balls, forgot Castlevania: OoE.
Man, what a year actually. Great games all over the place. Regardless of what platforms you own.