That is one of the most frustrating things a game can do - especially an RPG.
I don't even do every sidequest in most games, but just the idea there's something I might miss if I leave the area (and there's no system to track it in-game and return) triggers some kind of OCD and makes the game almost unplayable for me.
It's not even just leaving an area. It's backtracking to an area that you completed hours ago in order to stay in an inn or randomly talk to a person.
There is no indication in the game that you should head back, by the way. You just have to know that at a certain point of the story you should head back (and this is prior to you getting an airship, so it takes some effort to backtrack) in order to trigger something.
Even better, there may be sidequests that have multiple steps, and each step can only be completed in a certain window. Miss a single step, and you fail the sidequest and it gets locked off.
http://thegameawards.com/nominees/
Yep, Jeff's currently at the top spot for "Trending Gamer."
You know it's a weird year for gaming when you look at the list of GOTY candidates and realize that only ONE of them has a realistic chance at Giant Bomb's GOTY. Moreso, I don't think all of the nominees will even make their list.
And it's not due to an overabundance of games this year, either. Cue discussion of Brad talking about how he could only come up with 5 games that will definitely make his list.