All these level ideas remind me of the Cool Ghosts video on Hitman:
https://www.youtube.com/watch?v=JC-muSM6_0g
The most important point they made was that Sapienza worked because the setting was not "normally non-intriguing place with something weird happening that needs explaining" (as was the case with episodes 3 and 5 to their detriment, I think), but "place that needs no explanation to be intriguing". Everything weird in Sapienza naturally fits (except the biolab) in the setting, so no "narrative real estate" is wasted explaining why there's an observatory with a plague doctor outfit (ingeniously, I don't think a single NPC said a single line about those things).
Marrakesh and Colorado were set in relatively mundane locations that have exciting stuff happening, but that means we end up spending most of the level hearing about how things got to be this way. Paris and Sapienza on the other hand were about the story that develops while 47 is in the level: What happens when Novikov comes face-to-face with various key characters? What happens when Francesca discovers how deep Silvio's plans go?
So for season two I hope IO will continue to focus on intriguing settings that need minimal explanation, not "setting A with incongruous B happening". Don't have, say, a shopping mall that has been overrun by a local prison break or an amusement park that has been rented out for the day by a religious cult.