I'm assuming that Sheamus is going to win. It makes sense, he needs a World title win to get him out of the floundering limbo he's been in for months, and Bryan, as the cowardly heel who gets out of everything, needs to have someone stick it to him.
I'm not concerned about who wins at WM, and Sheamus is deserving of a face title run. What I am concerned about is the aftermath. I hope they realize Bryan is good material for the main event, and don't drop him back to mid card. I would say he's been a much bigger success as a cowardly heel champ than Miz or Del Rio were, surely he's earned some good will?
The obvious thing to me, is for Bryan to continue a feud with Sheamus past WM, and stay in the main event scene for the foreseeable future, even if he isn't champion. Maybe Barrett, when he's back in the summer, can take the title from Sheamus. Of course there's Orton to consider,too.