Well, this confirms what many of us assumed was happening back in 2020...
All I know is early in the pandemic you'd hear all about how HCQ was experimental but no mention of the same for ventilators.(Both having mixed results) FWIW since it's a new virus all treatments are effectively experimental.I seem to remember some posters here being pretty sure that HCQ was no good. Despite being used worldwide by a lot of actual doctors.
Genetic variants of COVID-19 are expected as viruses mutate all the time. Coronaviruses mutate slower than most RNA viruses, with an average rate of two nucleotide changes per month. A random mutation may make a virus more fit leading to an evolutionary advantage, as in what happens with natural selection, survival of the fittest.. from the viruses standpoint. …or the mutation could have no impact on its survival. Eventually, a viral variant with an evolutionary advantage will become the dominant form of the virus. Worldwide there are twelve key clades or variants of the SARS-CoV-2 virus. Sometimes the increased spread of a viral variant can only be attributed to chance. If a virus with a new mutation is carried by a super-spreader, moves to a new uninfected location, or is introduced to a new segment of the population, its rate of spread will increase. The U.K. variant has become the dominant variant in multiple regions of the world, which means it’s less likely a coincidence. Each time scientists identify a new variant. It raises the questions: does the mutation increase the viral transmission rate, does it cause more severe disease, and will the current vaccines or a previous infection still provide protection?
It's starting.
Well, this confirms what many of us assumed was happening back in 2020...
Thank you for taking the time to respond and excellent points all around.This is not a recommendation by the journal, its a review article published in the the journal that looks at numerous possible therapies (one of which is HCQ). It's also bizarre because the article was published now, because it seems to have been written in July of last year. Not a single one of its citations is after July 3rd, and it references COVID case numbers that we surpassed in April of last year.
Anyways, as has been discussed in this thread ad nauseum, we have numerous excellent quality randomized controlled times since then that have shown that HCQ is useless. There's a reason that Trump never took it when he became ill himself.
What the hell? I assume this will affect the Oxford/Astra-Zeneca vaccine's availability in the US? Or was that being manufactured outside of Europe? That is literally the ONLY "traditional" vaccine for COVID, and the only one that I'd remotely entertain taking. Hopefully it will be available in the US.
Different type of vaccine being developed at Scottish factory of a French company - an “inactivated whole virus” - UK task force secured 60m dose preorder in July for €470m with options for 130m more 2022-25, invested in factory. EU finalised first order of 30m this month.
Basically the Government through @katebingham acted like a venture capital fund, funding many vaccine candidates, expensively, across different types of tech, with companies from different countries (at time of some scepticism that a working vaccine could be produced so quickly)
Though despite the fact French Valneva had been funded for its vaccines in general in 2018 by EU’s investment bank, UK funding guaranteed its production in UK (speculative VC style investment) - similarly UK signed deal with Pfizer for German developed/ funded Biontech vaccine
UK approach explicitly focussed on speed (and boosting poor UK vaccine supply chain), at expense of cost. cost of individual batches, and cost of investing in spread of vaccines, not all would eventually be needed/ used... EU focussed on lower price, & helping smaller EU nations
approach with Astra Zeneca went further - UK Govt via Matt Hancock involved in matchmaking AZ with Oxford University, funded early clinical trials that eg enabled private jets to ferry samples etc - 100m doses and pricing at cost were part of that deal struck at April wave 1 peak
Important thing is AZ was not a vaccine specialist - alliance was encouraged by Govt, ie other possible ones being considered by Ox were effectively blocked by Hancock because of national interest. Not sure EU approach clocks intimate involvement/ risk taken by UK Govt here...
good news for everyone, is that UK should, in theory, have access to too much vaccine over course of this year, and could therefore be in a position to help. Already tens of millions of Oxford vaccine is being mass manufactured in India and shipped to other developing countries..
appropriate analogy here with EU would have been it at an early stage funding and developing Biontech in Germany (it did). But then at point Biontech did a deal with Pfizer, either have blocked that or insisted on first use in the EU, and paid handsomely, over odds for pleasure
Government playing EU-AZ spat very straight - even AZ supply chain stretches into EU. And we don’t know which is the best performing vaccine, and that matters as we expect this will become an annual event... UK, may yet be reliant on EU vaccines in future...
Things to discuss:
-Paying over odds for quicker vaccines, & for some vaccines which will never be used can still be vg value for money vs lockdown cost.
-Did UK turn necessity of coping with poor vaccine supply chain to advantage?
-Were EU listening overly to its big Pharma cos?
Great interview from @katebingham2 with Nick R - says that the NHS registry of 400k volunteers for super rapid clinical trials as well as help with manufacturing were crucial in getting round natural size disadvantage on vaccines. will be seen as post Brexit model - UK as “lab”
On AZ issue she points out UK was already building out Oxford vaccine manufacturing capacity from one year ago, two months before AZ deal signed (and at the time a deal was being negotiated with US company) AZ deal required those 100m doses for UK and at cost pricing
But it’s a race where you win much more than the total stake if any of your horses merely cross the line ... and you get your winnings more quickly the earlier the bet is placed...#
For much of the past year, across Europe and the wider world, schools have been closed. Was this a morally justifiable policy? We spoke to teachers and one former teacher, now MP, to find out: what is the reality on the ground? What is the impact on children’s lives? At the end of it do we think it was the right decision? Katharine Birbalsingh, Headmistress of the Michaela Community School in northwest London. Miriam Cates MP, Conservative MP and former science teacher and Alex Gutentag, a public school teacher from Oakland in California. Each of them comes to a different conclusion but they agree on one thing: the impact on children of such an extended period of school closures is very grave.
Kate Andrews, James Forsyth and Katy Balls break down the latest coronavirus news with Andrew Neil. Kate Andrews, The Spectator's economics correspondent, examines the data driving the government's response to the crisis, while the political team assess the ongoing EU/AstraZeneca row.
The EU flexing its powers and potentially witholding vaccines, while at the same time demanding those made in the UK.
Sinister, to say the least.
I would do the same as well.
EU changed their mind. Utter shitshow.
Not true, AZ was handed 300M € by EU to ramp up production. It is also explicitly stated in the contract that all sites including UK sites are to produce the vaccine for EU. Lastly it is also specifically stated in the contract that the number of doses to be delivered will not be affected by obligations with other customers. The claims by the CEO that they have to deliver to UK first, because UK ordered first are bs. Essentially AZ tried to defraud EU by taking EU money then claiming some bullshit production problems at EU sites and exporting vaccine meant for EU to UK.A really interesting series of tweets from BBC's economics editor Faisal Islam, please forgive the formatting, but thought it would be good to document here (thought it would be better to it this way rather than embed a dozen tweets)
TLDR, UK Government and Oxford/Astrazenica vaccine was more than just a commercial deal, it was a proper investment from even before Oxford and AZ had an agreement. Investment into infrastructure and NHS volunteer resources was provided by the UK government, and UK first option for all UK produced Oxford/AZ vaccines was part of the deal struck last April. EU's deal for the Oxford/AZ vaccine was a commercial only deal with little investment (they invested elsewhere) and haggled for lower cost. EU now paying for that lack of investment with major supply issues.
The UK Government invested in facilities before arranging the deal between Oxford University, and subsequently provided facilities (essentially driving the early trials) and personel (via NHS Volunteer register) in the arrangement put together in April, and the 100m dose and option to have first dibs on all vaccine made in the UK was part of that. Feel free to review a series of tweets by BBC's Economics Editor Faisal Islam on that.Not true, AZ was handed 300M € by EU to ramp up production. It is also explicitly stated in the contract that all sites including UK sites are to produce the vaccine for EU. Lastly it is also specifically stated in the contract that the number of doses to be delivered will not be affected by obligations with other customers. The claims by the CEO that they have to deliver to UK first, because UK ordered first are bs. Essentially AZ tried to defraud EU by taking EU money then claiming some bullshit production problems at EU sites and exporting vaccine meant for EU to UK.
Eventually they will suffer for this. Just ask Microsoft or Google how it went for them...
Evolutionary biologists Heather Heying and Bret Weinstein join Bill Maher to discuss the nature and possible origins of the SARS-CoV-2 coronavirus. (1/29/21)
I'm eligible for the vaccine early because of a preexisting condition, but there's no data on those who take some of the meds I take with the vaccine. So I might be put in the position where I have a tough call to make. Get the vaccine and risk it or wait for data to see if it's safe.
Vaccine manufacturer Moderna has told Italy and France it will deliver fewer doses than expected in February, in another blow to struggling coronavirus vaccination plans in the EU. Domenico Arcuri, the Italian special commissioner in charge of Italy’s pandemic response, said Moderna had told Rome that delivery volumes would be 20 per cent less than planned from early February.
I'm eligible for the vaccine early because of a preexisting condition, but there's no data on those who take some of the meds I take with the vaccine. So I might be put in the position where I have a tough call to make. Get the vaccine and risk it or wait for data to see if it's safe.
I'm eligible for the vaccine early because of a preexisting condition, but there's no data on those who take some of the meds I take with the vaccine. So I might be put in the position where I have a tough call to make. Get the vaccine and risk it or wait for data to see if it's safe.
I have, he didn’t make a recommendation quite yet. He said he wanted to see if there’s so,e data by the time I get the call for the vaccine. If not, it’ll likely be my choice based on his recommendation. Right now I’m leaning toward it, but the meds I take are biological so it’s not like taking aspirin or whatever or typical allergy meds. I assume it would be ok and that many of the people who’ve gotten them are also on these drugs, as they’re often used to treat rheumatoid arthritis and since we’ve vaccinated many elderly people already, I assume a decent amount of them have taken these drugs to treat that, I think it would’ve been made known if there was any bad reaction.If it helps perspective, the UK has now vaccinated 8 million people. They are the eldest demographic of age groups and most are likely to have preexisting conditions and are on various medications. My uncle has had both his jabs, and my mum is scheduled to get hers done on Wednesday.
We have yet to see any major publicity over any kind of serious conflict with either mediations or preexisting conditions apart from a couple of extremely hyperallergic people. I would suggest there's a lot of data taken from this already.
If you are concerned, give your doctor a call and have a chat about it, so you can make an informed decision for yourself.
Isn't weird how it is evil to say "china virus" but its totally cool to say "britisch variant" or "brazilian variant"?
What's with all this sudden talk of Country X variant?