52 episodes (S1+S2) was already a syndication package. A TV station can buy it and slip it on one day a week (probably a weekend) and leave it there for a year.
65 episodes (S1+S2+S3) is a better syndication package, because they can put it on five days a week for one season.
26+26+13=65
Yup. That's a wrap.
65 is the magic number for syndication. One episode every weekday for 13 weeks. Friendship is Magic is all nice and ready to be sold as one complete package deal.
We can just hope it pulls a DCAU. Batman, New Batman, Superman, New Superman, Batman Beyond, Justice League, Justice League Unlimited. Same series. With Static Shock as a spinoff, even. Perhaps a bit of an extreme example, let's just hope it doesn't pull a Pinky and The Brain. We really don't want My Little Pony and Elmyra...
There's really nothing saying that a show has to end at 52 or 65. Or that it needs to be "retooled" into something else at that point either. When a show gets canned or retooled at 52 or 65, it generally means that the show was having problems, and that whoever was supporting the show cut them some slack and gave them time to complete the bundle. Maybe if they're failing, they can also use the extra slack to prove that their formula works.
MLP:FIM is not in trouble. Statements from executives have suggested that their biggest concern is trying not to rock the boat. If it ain't broke, don't fix it.
GI Joe (A Real American Hero) for example hit 65 episodes after it's first season (if you combine the two movie-miniseries that got it started). After that it got another 30 episodes for S2 and a theatrical movie. I'm sure they were thinking that another 30 episodes for S3 (plus the movie broken into five chunks) would put together another 65 episode bundle (S3 ended up being 24 eps). But then they decided to retool the show mid-step to try and save money (outsourcing it to DiC instead of Toei) and kind of killed it.
It might not be up to the Hub at all if Hasbro doesn't want to do the show anymore.
The Hub is losing money. Hasbro is okay with that, because they fully expected it and it's part of their growth strategy. But they want The Hub to grow and get ratings, (and to do it using Hasbro IP so that the shows pull double-duty as advertisement and the toy sales go up). The Hub can't do that if Hasbro blocks them from using their best IP.
If MLP:FIM does well in the syndication market, MLP:FIM could theoretically outlast The Hub.