I'll preface by saying that I've got zero interest in LPS
The main reason I'm watching the show is for the main antagonists, Whittany and Brittany, the Biskit Twins.
Spoilers ahoy!
Quick background: They've got a rich, distant father who enables everything they do (Goodbye girls. Try not to get expelled today, hmm?), and a professionally-distant butler who appears to understand them completely. And they don't seem to know 100% what a "father" is (they referred to the Blythe's father as a "care-type person"). They're strange, and they don't seem to know the first thing about how to talk to ordinary people, and as a result, the entire school hates them (teachers and students). In apparent response, they've retreated into their twin bond, taken an "us against the world" attitude, and convinced themselves that they're winning.
In the first episode, Blythe was moving into a new city, and the Biskit twins snuck up on her out of thin air, like vampires or something. When Blythe said they scared her, they looked visibly hurt, and said "Yeah, we get that.
A lot." But then they tried to make friends with Blythe. They insulted her clothes, but then they offered to help her find better ones. And Blythe shot them down, because they were weird and creepy, and getting rejected upset them.
The next day, Blythe makes friends with a friendly multi-ethnic group of Biskit-haters. And the Biskits get over their anger and try again to make friends with Blythe, this time taking an interest in her interests by rudely looking in her sketchbook without permission. And Blythe shoots them down again, because now she's friends with the Biskit haters (which pisses them off again).
Then Blythe chooses to align herself with the Littlest Pet Shop, rivals of the Largest Ever Pet Shop owned by the Biskits' father. And she has the audacity to stick LPS flyers to their father's store. They decide to attack/humiliate her with pudding and cat litter in response, but of course it backfires. This also is the unveiling of an amazing new trait for the twins, they can put on the thinnest of disguises and they actually believe it makes them invisible. As in, they can dress up as cats, say "meow", and they honestly think that people will be fooled into not recognizing them. What an amazing world they live in.
A couple of episodes later, during gym class, an unusually large girl started being uncharacteristically-mean to all the other kids in class (apparently because standing out was an advantage for her for once), and she was particularly picking on the physically-inept Biskit twins, until Blythe jumped in out of pity and drove the giant off with hurtful words (try picking on someone your own size, oh wait, there is nobody your own size, you gargantuan freak). At which point "the whole school" was talking about how Blythe was best friends with the Biskits, something which very much bothered Blythe's new group of Biskit-hating friends. When Blythe considered accepting the Biskits' signs of affection, since the Biskits were obviously
trying to be nice, her friends straight-up said that the Biskits
do not deserve second chances. And then they snubbed Blythe for trying. The Biskit twins, on the other hand, were overjoyed and practically declared her to be their third twin. But then Blythe turned into a mean-spirited bitch, and when she realized what she was doing, she blamed the Biskits for making her do it. And the Biskits even let her vent her rage for a while, until Blythe said that she really hated the Biskits, and she was just using them for free stuff.
Basically they're some of the best villains I've ever seen.