Ozempic. Does it work?

Sand Dan Glokta

Sand Dan Glokta

Member
Found out today that my brother who is obese and his wife have been taking it for a couple months now, after my mother told me he has been sickly and lathargic lately. When asked he said its normal when starting off, then the symptoms will go away. Even though I could benefit from losing some kgs myself I'm dubious of anything that is sold as a magic pill.

Any personal experience? Long term side effects?
 
Sounds like anything around losing weight if you stop you can easily go back to worse than square one. If you just need lose a bit then why not try eating more fiber instead and don't do careless stuff like drinking that takeout coffee that has like 2 liters of syrup.
 
Sounds like you should be telling us, based on their progress, lol.

I was up to 125kg in early 2024, the biggest I've been (used to hover below 100 previously).

I lost a little weight during the 24 season (just from working a lot and not being home to over indulge etc.) and after the high season's end I started walking daily and cooking tons of chicken, broccoli, cauliflower, cabbage etc, with tons of low fat yogurt.

I had lost about 25kg by the 2025 season start. Then some more during the season. I went down to 85 during this year. I was eventually running 5Ks regularly and just recently scaled up to 10Ks. Still do lots of walking too though.

Now I'm up to around 90 so I need to be very careful with food again, I guess I'll spare me during the holidays but yeah it's a warning sign cos I actually wanted to go down to around 80, not gain up again.

I'm middle aged I guess now and the last time I had lost weight (down to 75kg over a decade ago) I did it by again watching the food and going to the gym, lots of treadmill and some whatever exercises/program some trainer cooked up but that shit's expensive now which is why I just hit the road.

Everyone is different so if you see a doctor and they say something else is a good fit then I'd say go for it, whatever works, so long as you change your lifestyle and not rely on it forever. You could first attempt dedicating an hour a day to walking, some more later, that should at least burn one meal.

PS: I bought an air fryer since I was cooking for myself a lot and I'd say it wasn't worth it, I do use it a lot since I got it but it just functions like a mini oven really, I got very similar results just shoving the chicken or whatever in the oven previously, it's nothing like frying (though I haven't tried fries yet). Maybe it would be a better choice if I bought a steam cooker instead like I was debating at the time but I figure that may also disappoint me and I'll just be going oh well, it's a minor difference to just boiling my vegetables or whatever else instead but maybe not, I dunno, haha, just saying.
 
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San Dan Glokta said:
Found out today that my brother who is obese and his wife have been taking it for a couple months now, after my mother told me he has been sickly and lathargic lately. When asked he said its normal when starting off, then the symptoms will go away. Even though I could benefit from losing some kgs myself I'm dubious of anything that is sold as a magic pill.

Any personal experience? Long term side effects?
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Wait, it's not a pill right? I mean I thought it was a shot. (If I was obese the fact I'd have to take shots of that would make me hesitate a bit.)
 
It's amazing loads of people refused to get COVID vaccinations but are willing to jab themselves once a week with a Type-2 diabetes medication regardless of the risks and quite severe side effects as a short cut to loose weight.

Anyway with any weight loss short cut you aren't training your brain not to be a fat cunt so as soon as you hit your target weight and you come of it your weight will just explode back on. And in the case of Ozempic you could end up with various other long term health issues as a result.
 
Oh, it works all right. I've seen several diabetic people take it and while the effects on weight aren't so often as dramatic as you see on celebrities (who also enjoy the best cooks and personal trainers money can buy, on top of the medication and quality medical assistance), the effects are visible. It's not as drastic as sleeve gastrectomy though, which can make people almost unrecognizable in some cases.

Too many people overestimate the results the average Joe can get by sheer willpower alone when it comes to losing weight. Most people need help, and many of them won't get it. I don't like to admit it because sometimes I like to imagine we live in a better world than the one we actually have, but the big pharma shills who say "if dieting, exercise and willpower worked, we'd have solved the obesity crisis by now" may be onto something.
 
Wildebeest said:
Sounds like anything around losing weight if you stop you can easily go back to worse than square one. If you just need lose a bit then why not try eating more fiber instead and don't do careless stuff like drinking that takeout coffee that has like 2 liters of syrup.
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mitch1971 said:
Stories I've heard. Hair lose. Failing eyesight.

To be blunt. Get off your arse and exercise (if you physically can).
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Senua said:
Do it the old fashioned way, you'll be healthier and feel a sense of achievement and self worth like never before
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I was more so asking for my brother's sake. And for the most part I agree.
dave_d said:
Wait, it's not a pill right? I mean I thought it was a shot. (If I was obese the fact I'd have to take shots of that would make me hesitate a bit.)
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Yes its an injection I know, I meant as an analogy.
ReBurn said:
It's great for controlling blood sugar and reducing A1C. Still need to eat healthy to lose weight on it. But it does reduce appetite.
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Thanks hot rod.
 
Don't you have to.keep taking it forever to keep the benefits and aren't there negative symptoms for not taking it? If true makes it a no go for me.
 
Chiming in here because my wife was on oral semaglutide (Rybelsis) for her Type 2 Diabetes and the doctor also said she'd lose a few pounds.

She did lose a few pounds. But after a couple months the losses (and the A1C improvements) plateaued so the doctor upped her dose. Then that plateaued, so he upped the dose again. She went from 3mg to 7mg to 14mg. She was on it for about two years and everything went to shit along the way. She was losing weight but it was no longer shedding body fat, it was shedding muscle mass. Then she had a minor fall from missing the bottom step and snapped her ankle and leg in three places. The orthopedic surgeon who repaired the fracture was appalled at how poor her bone density was at her age (53, at the time). Prior to taking Rybelsus, none of her doctors showed any concerns about osteoporosis or bone density. When the surgeon saw her chart and her list of medications, he immediately ordered her weaned off Rybelsus. When I asked why, he said there were too many conflicting studies about semaglutide causing bone density loss for him to trust it, especially for someone needing a severe fracture to heal.

She hasn't been on it since. Her A1C is perfectly fine without it. All the body fat she lost while on it? It came back despite her changed (and improved) eating habits. My opinion on these drugs is not very high. The "body positivity" movement swung far too one side but thanks to Ozempic and their GLP-1 kin the pendulum is swinging back to drug-induced anorexic looking zombies.
 
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I have not had the issues described in the post above but I can say that Mojurno does a fantastic job of helping folks (using myself as an example) with Diabetes Type 2. I have managed that differently over the years mostly using a ketogenic diet focus on reducing my intake of carbs and refined sugars.
Personally, I have lost a lot of weight, and i mean A LOT of weight over my life, I am a typical "rollercoaster" dieter and I use a keto diet for that. I also know I use food (instead of drugs or alcohol) as a coping tool that contributes to the weight never staying off.

What Mojurno does for me is removes the desire for the food I typically lean on. For the first time in my life I don't want sweet shit, candy, dessert, etc. Yes I have lost a lot of appetite and yes I have to force myself to eat more protein than veggies to keep the weight loss to fat instead of muscle but my blood sugar is fantastic.

It isn't a solution for everyone, and I cannot speak to long term bone density effects like the post above mine, but as someone who has ALWAYS struggled with controlling what I eat, this medication has been fantastic.

YMMV
 
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Dieting can be easy, I recommend that.
Don't even need to exercise to lose weight.
Have weetbix for breakfast and lunch and whatever you want for dinner and it'll melt off you.
 
Nydius said:
Chiming in here because my wife was on oral semaglutide (Rybelsis) for her Type 2 Diabetes and the doctor also said she'd lose a few pounds.

She did lose a few pounds. But after a couple months the losses (and the A1C improvements) plateaued so the doctor upped her dose. Then that plateaued, so he upped the dose again. She went from 3mg to 7mg to 14mg. She was on it for about two years and everything went to shit along the way. She was losing weight but it was no longer shedding body fat, it was shedding muscle mass. Then she had a minor fall from missing the bottom step and snapped her ankle and leg in three places. The orthopedic surgeon who repaired the fracture was appalled at how poor her bone density was at her age (53, at the time). Prior to taking Rybelsus, none of her doctors showed any concerns about osteoporosis or bone density. When the surgeon saw her chart and her list of medications, he immediately ordered her weaned off Rybelsus. When I asked why, he said there were too many conflicting studies about semaglutide causing bone density loss for him to trust it, especially for someone needing a severe fracture to heal.

She hasn't been on it since. Her A1C is perfectly fine without it. All the body fat she lost while on it? It came back despite her changed (and improved) eating habits. My opinion on these drugs is not very high. The "body positivity" movement swung far too one side but thanks to Ozempic and their GLP-1 kin the pendulum is swinging back to drug-induced anorexic looking zombies.
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I'm so sorry for what your wife has been through. I might forward this post to my brother as a warning
 
I work with all women and they're all on it. It does work but I would recommend trying to just change your lifestyle without it.

That said, obesity leads to all kinds of issues. If you gotta do it, its your body. No judgment from me.
 
Yes it works but I'm also convinced there will be daytime TV ads asking you to join a class action lawsuit 20 years from now if you had taken it.
 
HoodWinked said:
slows digestion, so ya of course it works. prevents you from stuffing your face otherwise you throw up.
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One of my coworkers ordered Chipotle today. Starving, she said. She ate 3 bites then tossed it. Said she felt nauseous so she stopped. She's lost 20 lbs this year. 🤷‍♂️

Sounds miserable to me. These people can't shit either. But if someone is desperate, I guess it works.
 
Nydius said:
Chiming in here because my wife was on oral semaglutide (Rybelsis) for her Type 2 Diabetes and the doctor also said she'd lose a few pounds.

She did lose a few pounds. But after a couple months the losses (and the A1C improvements) plateaued so the doctor upped her dose. Then that plateaued, so he upped the dose again. She went from 3mg to 7mg to 14mg. She was on it for about two years and everything went to shit along the way. She was losing weight but it was no longer shedding body fat, it was shedding muscle mass. Then she had a minor fall from missing the bottom step and snapped her ankle and leg in three places. The orthopedic surgeon who repaired the fracture was appalled at how poor her bone density was at her age (53, at the time). Prior to taking Rybelsus, none of her doctors showed any concerns about osteoporosis or bone density. When the surgeon saw her chart and her list of medications, he immediately ordered her weaned off Rybelsus. When I asked why, he said there were too many conflicting studies about semaglutide causing bone density loss for him to trust it, especially for someone needing a severe fracture to heal.

She hasn't been on it since. Her A1C is perfectly fine without it. All the body fat she lost while on it? It came back despite her changed (and improved) eating habits. My opinion on these drugs is not very high. The "body positivity" movement swung far too one side but thanks to Ozempic and their GLP-1 kin the pendulum is swinging back to drug-induced anorexic looking zombies.
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Post-menopausal women need to be extremly careful about their bone health. My mom is on Ozempic, but takes vitamans and minerals and does daily exercise to keep her bones and joints healthy.

Supplements are not optional if you are on GLP1s in my opinion.
 
San Dan Glokta said:
Found out today that my brother who is obese and his wife have been taking it for a couple months now, after my mother told me he has been sickly and lathargic lately. When asked he said its normal when starting off, then the symptoms will go away. Even though I could benefit from losing some kgs myself I'm dubious of anything that is sold as a magic pill.

Any personal experience? Long term side effects?
Click to expand...
I would encourage overweight people to just try only drinking water. Keep your food the same and get rid of the sugary drinks. You'll be amazed at what that does. Eventually you will need to change your diet but that one thing will have a big impact.
 
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So sad how widespread these GLP-1 drugs are becoming. Hundreds of millions will ruin their health for a bit of easy weight loss. I can only pray there will be a reckoning in a few decades.
 
On facebook there was a lot of storries about Ozempic. They liked to talk about which celebs probably used ozempic and who didnt. Worth a try I think.
 
Exercise is evidence and thoroughly reducing sugar intake for weight loss. I'm not aware of weight loss drugs, "Diet pills work by reducing appetite (making you feel full), blocking fat absorption, or boosting metabolism to help you eat fewer calories"
 
San Dan Glokta said:
Found out today that my brother who is obese and his wife have been taking it for a couple months now, after my mother told me he has been sickly and lathargic lately. When asked he said its normal when starting off, then the symptoms will go away. Even though I could benefit from losing some kgs myself I'm dubious of anything that is sold as a magic pill.

Any personal experience? Long term side effects?
Click to expand...
It does work but is not a miracle drug. It makes you crave food less, thus you eat less. However your body gets used to it and you need to increase the dosage, at some point you need to stop. Same as with many medicines. If you didn't make changes to the way of life you will start eating again and the weight will come back.
 
T-0800 said:
I would encourage overweight people to just try only drinking water. Keep your food the same and get rid of the sugary drinks. You'll be amazed at what that does. Eventually you will need to change your diet but that one thing will have a big impact.
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Giving sugary drinks is nothing else than giving up smoking - your brain craves it so it will fight you.
 
Sodas etc. is the one pleasure/addiction I still allow myself to indulge in all this time but I go for 0 calorie versions which to me taste the same anyway. Been going for stevia based since those became a thing years ago but occasionally still get regular with aspartame if it's way cheaper due to deals.

But I already drank those when I reached the 125kg, I imagine I'd have exceeded it a ton if I was drinking sugar stuff on top. Otherwise yeah it was mostly food and lack of exercise. But yeah I don't think 0 cal stuff are bad at all, I'd probably not have lost all this weight as I really drink too much of it.
 
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Been on Mounjaro for 6 months. It's fucking magic. Blood work is elite now. Compound lifts are way up. BMI super improved. It's for life, of course, no coming off it ever.

www.menshealth.com

Why Are Fit Guys Microdosing GLP-1s?

Healthy people are injecting tiny doses of obesity medication to look and feel even better. But at what risk?
www.menshealth.com www.menshealth.com
 
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Cyberpunkd said:
Giving sugary drinks is nothing else than giving up smoking - your brain craves it so it will fight you.
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Depending on your diet. Since I switched to keto I consume zero sugars and I don't crave it at all. Used to be a heavy drinker of soda. I don't crave anything now, I'm full so fast I need to remind myself to eat
 
TexMex said:
Yes it works but I'm also convinced there will be daytime TV ads asking you to join a class action lawsuit 20 years from now if you had taken it.
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There's already a MDL (multi-district litigation, a cousin to class action) against Novo Nordisk with nearly 3000 related lawsuits alleging they weren't warned of the significant and severe potential side effects like gastroparesis, vision loss, and others. I'm thinking class action suits will start popping up in the next few years.

Chittagong said:
It's for life, of course, no coming off it ever.
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Exactly what Big Pharma loves to hear.
 
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Ocean Dweller said:
yes
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No, it rewires your brain. The problem is as always people do not want to commit to something long term, for many it's a choice between:

1. Changing their lifestyle, exercise and diet
2. Doing nothing and taking Ozempic

Of course many will take the second option, but at some point it stops being viable.
 
Nydius said:
There's already a MDL (multi-district litigation, a cousin to class action) against Novo Nordisk with nearly 3000 related lawsuits alleging they weren't warned of the significant and severe potential side effects like gastroparesis, vision loss, and others. I'm thinking class action suits will start popping up in the next few years.
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Article:
An analysis by University Hospitals Cleveland Medical Center of records from the TriNetX database found that the number of patients diagnosed with gastroparesis after being prescribed a GLP-1 receptor agonist (0.1% of the patients) was 250% greater than the number of patients diagnosed with gastroparesis who did not take a GLP-1 medication (0.04%).[28]

Oh. That might be a problem.
 
Why don't people just stop trying the easy way out with drugs and just work on getting plenty of exercise and eating better?
 
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There's this new peptide that's in the testing phase in the FDA that is apparently better with little to no side effects. If you're set on taking Ozempic, it might be better to go for that instead. Results come out on 2026 iirc.

I personally did it the old fashioned way. It does take some discipline and time though. That's usually the issue that comes up when I ask people who want to lose weight. No time for cardio, meal preps or healthy alternatives are more expensive.
 
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