• Hey Guest. Check out your NeoGAF Wrapped 2025 results here!

Ozempic. Does it work?

Semaglutide should not be an easy way out for those who can still turn their lifestyle around, of course.
It's a diabetes drug first and foremost.
That said, there's a lot of people who are way beyond the point of no return regarding obesity, and for which surgery is not an option due to age or other complications already induced by obesity (joint damage, cardiovascular strain, atherosclerosis, thrombotic risk, etc). Ozempic/Mounjaro should definitely be a stepping stone for them. And those drugs should always be accompanied by a custom dieting and exercising program anyway.
 
I don't know because I haven't tried it (nor want/need) but the mechanism of action restricts your hunger by slowing digestion. That, to me, sounds horrifying, slow motility is an issue for a lot of people.

OP if you want to lose weight it is very (very easy). Cut sugary shit as much as possible and walk, that's really it. If you want to lose faster walk right after you wake up (your glycogen levels are low and the body will have no other choice than to mobilize and metabolize fat).
 
Last edited:
Ariana Grande GIF by mjm1724
 
I've never used it but it definitely works. With GLP-1s we may cure rampant obesity in America within a decade or so. They definitely have side effects though from what I've heard from people who take them. Diarrhea, vomiting, among other things. The ideal way to lose weight is diet, exercise, lifestyle changes, but the reality is many can't or won't do it, so these drugs have been wonders for people.
 
Jinzo Prime said:
Article:
An analysis by University Hospitals Cleveland Medical Center of records from the TriNetX database found that the number of patients diagnosed with gastroparesis after being prescribed a GLP-1 receptor agonist (0.1% of the patients) was 250% greater than the number of patients diagnosed with gastroparesis who did not take a GLP-1 medication (0.04%).[28]

Oh. That might be a problem.
Click to expand...

Well, that's partially how it works. GLP-1 is supposed to slow stomach emptying and promoting satiety. It's like taking a blood thinner - you expect the side effect of increased risk of bleeding.
 
The way to think about these drugs is like insulin, something a broken body doesn't do well enough. For whatever reason, some people have poor activation of GLP-1 and GIP signalling, which makes them hungry, fat, causes poor blood values, inflammation. The drug gets them back to a healthy level.
 
Cyberpunkd said:
All the fat people will get back to being fat the moment they stop taking the drug. This is not a cure, healthy living and better quality food is.
Click to expand...
Well that's a lost cause. Whatever you want to call it, I believe obesity rates in America will plummet over the next decade. Whether that qualifies as a cure, as a fool's gold, as a band-aid, as a patch, whatever it is, I consider that a good thing. Don't let the perfect become the enemy of the good. I think we should embrace lower obesity numbers any way we can get them.
 
Cyberpunkd said:
All the fat people will get back to being fat the moment they stop taking the drug. This is not a cure, healthy living and better quality food is.
Click to expand...
A lot of times they go back, but there are people whose mentals become stronger after they've lost the weight and learn how to keep it off, because those types were miserable and didn't know a way out of their situation at the time. Learning from your mistakes should be easy and something repeatable. I don't talk down on people who don't, because I used to be one, myself. Now, I am willing and ready to learn, at all times. Observe, rather than come up with an answer to any/everything, right away.
 
DragoonKain said:
Well that's a lost cause. Whatever you want to call it, I believe obesity rates in America will plummet over the next decade. Whether that qualifies as a cure, as a fool's gold, as a band-aid, as a patch, whatever it is, I consider that a good thing. Don't let the perfect become the enemy of the good. I think we should embrace lower obesity numbers any way we can get them.
Click to expand...
I mean - if they will keep the weight, kudos to them. I just think in the past few decades we have a lot more education about physical health, numerous initiatives to improve food quality and people get fatter. I think instead of the drug (again if it works - great, I just don't think it will) we should be looking at health education, and most importantly - taxing the shit out of bad food. You will mysteriously notice when companies have money on the line they will suddenly figure out how to make their food healthier.
 
I'm not on Ozempic -- but Mounjaro -- and yeah, I can say it definitely works. Me personally, I've had no side effects, and on average I've been losing about a pound of week.

It's a helpful tool, but if you want to ever stop taking it - you've gotta make all the smart lifestyle changes too.
 
killatopak said:
There's this new peptide that's in the testing phase in the FDA that is apparently better with little to no side effects. If you're set on taking Ozempic, it might be better to go for that instead. Results come out on 2026 iirc.

I personally did it the old fashioned way. It does take some discipline and time though. That's usually the issue that comes up when I ask people who want to lose weight. No time for cardio, meal preps or healthy alternatives are more expensive.
Click to expand...

Retratutide. It's the new get go drug even for body builders. Its on phase 3 clinical trials now and is expected to be FDA approved by 2027.

If I were to start losing weight now, I would try the traditional way first (nutritionist, personal trainer, endocrinologist, etc). If you succeed... better. If not, you'll probably have a much more effective drug available by the time you fail :)

Cyberpunkd said:
Giving sugary drinks is nothing else than giving up smoking - your brain craves it so it will fight you.
Click to expand...

Switch to zero sugar for a while, then to pulp juice (at least were i live it's dirt cheap and have practically zero calories) with stevia, lemon and carbonated water. Infinitely better than sugary drinks. Plus near zero/zero calories.
 
Last edited:
Gp1 said:
Retratutide. It's the new get go drug even for body builders. Its on phase 3 clinical trials now and is expected to be FDA approved by 2027.

If I were to start losing weight now, I would try the traditional way first (nutritionist, personal trainer, endocrinologist, etc). If you succeed... better. If not, you'll probably have a much more effective drug available by the time you fail :)
Click to expand...
Wild at the amount of money that's getting spent on finding ways to prevent people from essentially just not stuffing their face with nachos. I get the public health importance of tackling the obesity crisis, but when you step back and look at first principles its just seems like a needlessly sophisticated solution to a simple problem. This reminds a lot of the framing pharmaceutical companies provided with SSRIs, arguing that mood disorders represented a "chemical imbalance" when in reality the drugs have never been proven to be more effective than structured behavioral therapy.
 
Last edited:
Dr.Guru of Peru said:
Yeah, that white ceramic lake tahoe is sexy.
Click to expand...
If someone likes a washed out brand that released hundreds of limited editions in 2010s. Which is a shame because my late grandfathers wish was to own an IWC one day. They also obviously paid for product placement, given that Sheeran is a hardcore PP guy.
 
Dr.Guru of Peru said:
Wild at the amount of money that's getting spent on finding ways to prevent people from essentially just not stuffing their face with nachos. I get the public health importance of tackling the obesity crisis, but when you step back and look at first principles its just seems like a needlessly sophisticated solution to a simple problem. This reminds a lot of the framing pharmaceutical companies provided with SSRIs, arguing that mood disorders represented a "chemical imbalance" when in reality the drugs have never been proven to be more effective than structured behavioral therapy.
Click to expand...

It's easier to just stuff yourself with nachos than (IF you are a normal healthy person, without any medical alteration):

Undo years of food emotional attachment +
Plan your dietary needs to know how many calories you have to eat +
Buy your healthy food while being bombarded with "nacho like" hyperpalatables everywhere +
Cook for an entire week (and maybe cook for your entire family) +
Partition your food for every meal, and find time to do everything above while having your daily routine +
Pull your healthy lunchbox while everyone is feasting on nachos around you.

The solution is very simple and known but it takes a lot of discipline. In broader terms you just have to burn more calories than you ingest, while trying to create muscle by weightlifting and consuming a fair share of protein.

The problem lies on the execution.

Its way easier for to just take a shot and see the results fast because you simply don't fell hungry than do everything i wrote, although you still need to change your life style. (considering that the person even has the knowledge about it)

Plus with Retratutide you even has the benefit that it accelerate your metabolism so you don't lose too much muscle while losing weight (no more Ozempic head).
 
Last edited:
DragoonKain said:
With GLP-1s we may cure rampant obesity in America within a decade or so.
Click to expand...
Unless your weekly shot costs less than a McD burger, this won't happen.
The people who need these drugs the most are also probably those who can't afford it.
Even countries with universal health care give these drugs only to diabetics. Obese people who don't have diabetes must pay for the drugs in full, and in the current economy, it's a price not many people can afford.
 
I've had 3 friends take Mounjaro and they've all came off it. One ended up in hospital with kidney issues, the other wouldn't stop having what we called "Godzilla burps" which smelt like vomit that was on fire and the other started collapsing regularly. That being said I've known people that have taken it without issue so it certainly seems to be luck of the drawer when it comes to side effects.

One of the guys is now on retatrutide and is doing much better. He was around 620 pounds but is now down to about 500.

As most others have probably pointed out though, if you don't fix the underlying issue that caused you to be in that situation the first place, you'll bounce back once you come off it. Fixing your relationship with food and having a more active lifestyle should be the number one priority.
 
Yes it does, I share an office with someone who was around 134kgs in January he was prescribed Ozempics at a low dose (0.5mg) and he is actually losing alot more weight that I thought he would, but it motivated him to start eating healthier and workout more which definitely pushed it really forward positively, Idk where he will be at in a year but what I see is an impressive result
 
Sand Dan Glokta said:
Found out today that my brother who is obese and his wife have been taking it for a couple months now, after my mother told me he has been sickly and lathargic lately. When asked he said its normal when starting off, then the symptoms will go away. Even though I could benefit from losing some kgs myself I'm dubious of anything that is sold as a magic pill.

Any personal experience? Long term side effects?
Click to expand...
Doesn't it just make you eat less, by stifling hunger?

You know what a cheaper drug-less method would be? Become so poor that you can't afford to eat for more than $50 in a month. You'll be forced to eat less, make sure the dishes are as nutritious as possible and that most ingrendients are whole foods, like beans, lentils, eggs etc. The less you eat the less calories you'll put around your waist.

You won't even need to exercise to burn off fat.

T-0800 said:
Sure. For a few days.
Click to expand...
Quitting sugar completely can take a lot longer. The first time I tried to quit it took a year actually. If you're depressed etc. and lack good habits(because of reasons), then it'll be like cutting off one of few joys in life. And the body and mind will scream after it. Some people can quit cold turkey, but others like me, will need longer to make it sustainable.

It's better to think about it longterm, by cutting off sugar step by step. Go from eating every day to only Saturdays. Then from there to only rarely. And then to almost nothing, no sweets, candy, sodas etc. That way you have time to acclimatize your body and psyche and you can replace bad eating habits with good ones. In the end you'll not even crave sugar.
 
Last edited:
I took it for 6 months and only lost 5lbs so I stopped. BIG MISTAKE I gained 40lbs within a few months.

I started taking it again but I also asked my doctor to put me on Wellbutrin and that combo worked out fantastic. The semaglutide helps keep me from over eating and the Wellbutrin gave me the energy and confidence to hit the gym on a regular basis. Im now down 60 lbs and sitting at 199. Goal is to hit normal BMI which for my height is 183.
 
Cyberpunkd said:
All the fat people will get back to being fat the moment they stop taking the drug. This is not a cure, healthy living and better quality food is.
Click to expand...
I agree with you, which is why we ALSO need government to stop paying for shit food/sugar water via food stamps, aggressively educate on better eating habits, penalize companies growing crap versions of wheat and corn, and completely disengage with any company selling HFCS and sugar rich crap.

We live in a dietary cesspool that makes it too easy to be fat. And now we have decades of shit nutritional advice (avoid butter, eggs, limit meat, use these seed oils and chemically treated wheat flour instead!) we have to try to roll back so folks can understand that a twinkie should be viewed more like a cigarette (i.e. a dangerous indulgence) rather than a common, albeit tasty, snack.
 
It works but there's some of my colleagues who prescribe it for women who are 120lbs. It replaced going to the gym and the health and mental benefits that came along with going to the gym. Whenever I see someone questioning it on the internet I see people comparing it to anabolics but people on anbolics are usually gym rats.

We had to start treating it like a narcotic at my hospital because nurses and even pharmacists were stealing the GLP1's.

Personally I'm against it and encourage more activity and even OMAD and fasting.

GLP1's are a good alternative to bariatric surgery but if you don't change your lifestyle it's moot.

Lived through the Adapex abusers and seen a lot of doctors have their licenses stripped for over prescribing. This isn't the same of course but it should be treated the same.
 
Further to my earlier point of avoiding muscle loss on Mounjaro, fresh stat from today.

Pre-Mounjaro at 115kg bodyweight
Turkish getup max 20kg

On Mounjaro at 92kg bodyweight
Turkish getup max 24kg
  • 20/115 = 17.4% BW
  • 24/92 = 26.1% BW
  • a ~50% jump in relative load
 
Chittagong said:
Further to my earlier point of avoiding muscle loss on Mounjaro, fresh stat from today.

Pre-Mounjaro at 115kg bodyweight
Turkish getup max 20kg

On Mounjaro at 92kg bodyweight
Turkish getup max 24kg
  • 20/115 = 17.4% BW
  • 24/92 = 26.1% BW
  • a ~50% jump in relative load
Click to expand...
Thats an insane number. Congrats.
 
I'll never forget, about 9 years ago an overweight co-worker and myself were eating mcdonalds together for lunch.. she turned to me and said you know were fat cause we eat this a lot, right?

I looked her dead in the fucking eyes and said 'yep.'

Thats the end. People are fat cause they eat shit, and too much of it. It's simple as that. If you wanna lose weight, you gotta stop eating so much fucking food. Entire billion dollar industries have been built around the fluff of that shit. It's so simple
 
Nocty said:
I'll never forget, about 9 years ago an overweight co-worker and myself were eating mcdonalds together for lunch.. she turned to me and said you know were fat cause we eat this a lot, right?

I looked her dead in the fucking eyes and said 'yep.'

Thats the end. People are fat cause they eat shit, and too much of it. It's simple as that. If you wanna lose weight, you gotta stop eating so much fucking food. Entire billion dollar industries have been built around the fluff of that shit. It's so simple
Click to expand...
And people will get fatter. All those Uber Eats kinds of services now bring practically any food place to your door. And tons of students use it now too (my nieces included). And even worse, that delivered food is a rip off. So not only do people get fatter, but they spend more money too. Broker and fatter. Terrible combo.
 
Last edited:
Nocty said:
I'll never forget, about 9 years ago an overweight co-worker and myself were eating mcdonalds together for lunch.. she turned to me and said you know were fat cause we eat this a lot, right?

I looked her dead in the fucking eyes and said 'yep.'

Thats the end. People are fat cause they eat shit, and too much of it. It's simple as that. If you wanna lose weight, you gotta stop eating so much fucking food. Entire billion dollar industries have been built around the fluff of that shit. It's so simple
Click to expand...
It's simple in theory, brutally hard in reality for many.

I went through my own weight loss journey and I wouldn't have made it without my parents. I even had to live with them for more than a year. It was that tough. At that time I was cycling about 30 km a day between work and home and sticking to a very strict diet. The fat basically just fell off me. It was insane.
 
HRK69 said:
It's simple in theory, brutally hard in reality for many.

I went through my own weight loss journey and I wouldn't have made it without my parents. I even had to live with them for more than a year. It was that tough. At that time I was cycling about 30 km a day between work and home and sticking to a very strict diet. The fat basically just fell off me. It was insane.
Click to expand...

Yeah I feel you, I mean, it's the reason I've been fat as hell for most of my adult life

When I moved to Japan back in the days that shit became a real problem because the food there is fucking amazing and tons of cafes that serve pure gluttony for a fat nigga like me. I had basically no self control during those years and ballooned about 100lbs in 3 years during that time... I realised it was going to limit my life hard so I cut back, went cold ass meat fruit and veggies only for more than a year, dropped that 100lbs right back off. But I would be lying if I said I am skinny, far from it, I fluctuate like hell. I lose the weight then slip back into my old ways and bam, them rolls come right back bruh lmao

I swear one of these days I will get down and stay down but you know what, I'm getting well into midlife now and don't have any health issues yet so I'm running out of time. It's gotta get done, I gotta lock in.
 
Nocty said:
Yeah I feel you, I mean, it's the reason I've been fat as hell for most of my adult life

When I moved to Japan back in the days that shit became a real problem because the food there is fucking amazing and tons of cafes that serve pure gluttony for a fat nigga like me. I had basically no self control during those years and ballooned about 100lbs in 3 years during that time... I realised it was going to limit my life hard so I cut back, went cold ass meat fruit and veggies only for more than a year, dropped that 100lbs right back off. But I would be lying if I said I am skinny, far from it, I fluctuate like hell. I lose the weight then slip back into my old ways and bam, them rolls come right back bruh lmao

I swear one of these days I will get down and stay down but you know what, I'm getting well into midlife now and don't have any health issues yet so I'm running out of time. It's gotta get done, I gotta lock in.
Click to expand...
Yeah, that cycle you're describing is real as hell.

Midlife with no health issues not a bad place to be. You've still got time to lock in, just maybe in a way that doesnt require hating food or yourself. Progress doesn't have to be all or nothing imo. Respect for being honest about it. Being honest with yourself like that is usually the first step toward making it stick.

But damn, I love to eat. Today I demolished a 40×60 cm kebab pizza during movie time. Zero regrets. It was glorious.

Basically one of these but with kebab:

mQaWaIXGvy5LZgXd.jpg
 
Just wanted to share that a co-worker of mine ended up losing partial vision in his left eye taking GLP1s. It was from Non-Arteritic Anterior Ischemic Optic Neuropathy and is increased greatly when taking medications like Ozempic. He did lose some weight though! Sadly, I don't think that was worth the vision loss.

I hate how this drug is being pushed everywhere. I'm curious to see and hear about the effects within the next 5-10 years.
 
I think it does, but at the same time the side effects seem to be too much. Not surprising though, as you can't have "magic drugs" like that without heavy side effects.
 
You must log in or register to reply here.

Similar threads

Rosie O'Donnell after a year of Mounjaro (weight loss drug like Ozempic)
2 3
141
3K
Chittagong replied
Whose back to work??
44
535
Tomorrow replied
Vogue boss 'concerned' by return to skinny models (surge of ozempic)
2
61
6K
GymWolf replied
The growing subscription-based model in which we are consuming media now doesn't seem sustainable, does it?
22
386
near replied
Does it strike someone as strange that Reddit comment rating system is antagonistic by definition?
2
56
699
Avid Reading Horse replied
Top Bottom