Female Protag
Anything that I should know about, prior to playing the game?
Fine choice. She's a better character than Male protag IMO.
Tips:
Go to Paulownia Mall anytime you don't have a Social Link available (at night, too) to increase one of your three social stats (Charm, Academics and Courage).
Prioritize the Emperor, Star and Magician Social Links if you can, because their Ultimate Persona are mad OP.
Study
this. There are many more status changes than in 4.
If you want to pursue a romantic relationship with
Akihiko somebody, it's not just as simple as telling them you love them at Level 8/9. Flatter them throughout the link, and say things that you think they'd like to hear (i.e. "You're charming").
Never go to sleep in class. Academics is crazy hard to boost, so you need every bit you can.
Try to go for 1 miniboss every time you enter Tartarus so you can focus on raising attributes and night S. Links instead.
Worship Junpei like the god that he is, and talk to and reassure him every night in the dorm in November to get a bonus scene in January.