Well, my favorite genre is Fiction/Thriller. I enjoy a good suspense, chase type of book. I've got a close follow up to horror/sci-fi, but only if it doesn't get too deep into things like vampires which are more played out than zombies or goes way too deep into sci-fi nerddom.
One of my favorite books is called The Cobra Event, its a biological warfare thriller which I highly recommend, but only if you don't have a weak stomach. Richard Preston can often paint a very realistic picture of some gruesome scenes.
I know that probably doesn't help if you haven't read that either, but popular books like Snow Crash... I enjoyed, but didn't love. I've tried to get into Philip K. Dick novels, but his writing is a bit too flowery for my tastes. I enjoyed almost all of Asimov's books. As contrived as his writing is, I enjoy Koontz on occasion and when I can stomach 600 pages of filler, I"ll read King and enjoy it.