Eh, I don't think so. I think people look too strictly at RE's lore sometimes. The RE universe is structured in a way that standalone stories and event can happen without necessarily being about the core RE characters. I mean, look at RE4. Sure, Leon was there, but it was totally standalone from the stories before outside a few ties here and there. It was a Biohazard, albeit a different one than Raccoon City, in another place. That story could have easily had a different protag (although I'm glad they didn't, since I love Leon).
The honestly truth is, I think, they don't do a hard reboot, because there's really no point in it. You can have small scale outbreaks in other places in the universe they have set up. There's no reason to simply throw all the story and canon away just the sake of revisiting the original mansion as Chris and Jill. You can have a new area reminiscent of that, in a new way, just fine.