For beating the game on any difficulty, you get:
-S.T.A.R.S. Barry Costume
-RE2 Claire Costume
-Chicago Typewriter (Weapon)
-Classic Horror Screen Effect
For beating the game on Normal difficulty or above, you get:
-Crossbow (Weapon)
For beating the game on Survival Difficulty, you get:
-Meat Grinder (Weapon)
-No Escape Difficulty
For beating the game on No Escape Difficulty, you get:
-Infinite ammo for all weapons
For getting the Good Ending, you get:
-Sniper Claire Costume
If you clear the campaign in under 3 hours, you get:
-Infinite Ammo Rocket Launcher (Weapon)
For getting all S-Ranks on Normal, you get:
-Short Sword (Weapon)
-Sepia Toned Screen Effect
For getting all S-Ranks on Survival difficulty, you get:
-Comic Noir Screen Effect
For getting all S-Ranks on No Escape difficulty, you get:
-Cursed Video Screen Effect
For getting all S-Ranks on all difficulties (without using EX weapons), you get:
-Black & White Screen Effect
For completing all Countdown Missions, you get:
-Bubble Gun (Weapon)
For completing all Invisible Enemy Missions, you get:
-Katana (Weapon)