I want to clarify, I don't want a reboot. I think a big part of the appeal of the franchise is its continuity, lore, and how it just rolls with it all. I've said this before, I think Resident Evil is the longest on-going video game narrative, I believe it has more canon entries in its mythology between its different games, cg films, mangas, etc., that contribute to the series canon, but I think this aspect of the series is appealing, and the 'problems' with the series wouldn't be fixed with a reboot. Actually, a reboot is the last thing I want. I'd rather they just go to new characters and situations in the new universe rather than start it from scratch.
And yes, we have The Family now, but they have at this point in time, no charismatic qualities to them, they could be fleshed out into something interesting, but we'll have to see.
I don't mind there being more than one source of evil, I know in the series as it is now can support it, but it'd be nice to have villains that, like the main heroes in the games, are reoccurring and built upon between different entries.