Try getting an XL hand grip, I got one off one of those asian bargain webshops for like $4-something shipped(try looking around tinydeal.com, dx.com or focalprice.com). It's great, takes the strain off the thin console shape, highly recommendedDoesn't help with the weight issue, put it down and take 5 every once in a while to recouperate ^^;
Thanks, I'll definitely look into that (and wow that's way cheaper than I anticipated). For some reason Nintendo hw and my hands don't get along.
It'll be hard not to marathon-play this game so maybe I'll hold off until I have a more ergonomic setup for it.