Just thought I'd say, we still haven't had any serious XP SP2 issues, but we don't run a lot of "legacy" apps, as some larger companies would. It definately seems to work with Trend Micro's suite as far as I can tell, they also have an official "We support SP2" up on their website.
I'm not sure who thought Trend's products were a problem, but it doesn't seem to be so.. unless maybe they are running a really old version, but it would be surprising as Trend just quit supporting even mildly old versions due to needing to change their Virus update format.
Amazingly they had no clue they would eventually need 4 digit files, I guess.