Just played through the game with an i7 and didn't have that problem and neither have any of my mates had anything like that (there are few multicore ini tweaks that supposedly help with various issues), but there's fair amount of crashing here and there, mostly due to the autosaves like in other Beth games (it'll create an autosave, but crash immediately afterwards). Completely playable though and even though it's not as good as New Vegas I can definitely recommend it.It will freeze every 15 minutes while sound continues if you have a multicore processor, but I guess some people haven't had this problem.