It's also possible they will end this season with wrapping up the God/demons/angel/heaven plotline some how and next season will just focus on them being hunters again (if it ends up being the last season), but I doubt that would be the case.
They're gonna need a strong over arching story for them to just go back to being hunters. Because the last time they were really closest to being just hunters was season 1, even there we had the yellow eyes story / finding their father so they took jobs he had written about in his journal.
I guess you could argue season 2 was also about them being just hunters for the first half. But season 3 was when the demon / hell stuff started kicking in and then from season 4 onward angels have been major players.
Honestly I'd love it if they just went back to being hunters but that's really hard to do at this point because sam and dean have so many ways of killing things now it's crazy.
The reason the knife was necessary to the show in the first place was because demons went from being a rare occurrence where they had to set up the devil's trap carefully and then use an exorcism to the main villains.
If you wanna make em go back to being hunters I feel like you have to take almost everything away from them, like the bunker, their connection with angels, the knife, the colt (i dont even know where the colt is honestly) and just put them back in the impala with their salt shotguns and their trunk of stuff and give them some kind of incentive to track down monsters beyond "this is the job".