Never installed one on a NA car, but have played with bigger turbos and larger hotsides on factory turbo cars. Only difference is that you need to do some exhaust work on a turbo obviously. You're still messing with often stand alones for fuel, fuel pumps, and ICs. Sometimes injectors need to be upgraded as well. So the only less work you need is the exhaust though you'd probably want to change that regardless. If either go it's a hassle depending on your tune, but yes, wheel bits can be troublesome heh.
Belt + Pulley vs. push of a button/twist of a knob.
Not downplaying superchargers, they get the job done and some prefer the linear power and sweet whine, myself I prefer the sweet spooling sound and the surge of power (never actually heard a centrifugal SC oddly enough over all the years in person though). Just a matter of taste.