They make your workspace unavoidably look messy, but worse still its never a simple matter of sticking a headset on and getting going. Theres all this tiny stuff to be done first: turn on each controller, plugin the motion sensors, load up the SteamVR application, clear the floor
Its a first-generation problem, and it wont even be a problem for the most committed, but think about the number of people who have never once loaded up the settings menu on their TV or just hit play when confronted with a games title screen. Sure, PC gaming is a rarefied land of the technically savving, but thats not an all-encompassing truth. Until VR is as simple as putting the goggles on, it cant break out of its niche.
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The relative hassle creates another problem: laziness. Last night I spent so long sitting on the sofa and trying to summon up the energy to turn on all the various Vive components, clear old pairs of socks and bits of recently-shattered-while-wildly-flailing-in-a-headset LEGO AT-AT off the floor and go dick around in a virtual grand canyon, which I had been looking forwards to for most of the day, that it got too late and I had to go to bed. First world first generation problems.