A few thoughts after digging into the game a bit more today:
- The drug trade works well. It's a great way to make some cash, and you can easily make thousands of dollars on just one transaction. The game alerts you if you will get a high price for an item somewhere, so it's not just trial and error.
- The missions are challenging. I've failed a few of them several times. Some are a bit frustrating (the leaking tanker, the guy with the heart condition) but they are really creative and fun. None of them are too long though, which may be a negative point for some but I think it works since it's a handheld.
- Jacking supply trucks for drugs/guns is a great idea, but sometimes they are more trouble than they are worth. For the drug vans you can easily jack them, but for the Ammunation trucks you have to damage their truck badly enough for them to get out. The easiest way to do this is to do a drive-by, but if you take too long you really just get ammo you just used. It seems like a lot of work for no reward. Sometimes you get some awesome weapons like assault rifles.
- Some e-mails can be annoying. For example, when you shop Ammunation online, you get an e-mail confirming your order, and then another e-mail for when the guns arrive to your place (which is only a few seconds later). I know this is realistic and everything, but it's annoying to check these.
- There are a lot of cool random sidemissions. I was just walking around and went up to a hotdog vendor, and he offered me a mission to plant a bug on his wife's car. Nothing special, but it was pretty unexpected and a cool diversion.
- A cop was chasing me, and he crashed into a hotdog vendor (maybe the same one from before?) and exploded, killing the hotdog guy. Lulz.