This is all got debated in Parliament (except EU referendum of course):
EU Referendum Rules triggering a 2nd EU Referendum
870,894 signatures
Give the Meningitis B vaccine to ALL children, not just newborn babies.
823,346 signatures, now closed - failed.
Block Donald J Trump from UK entry
586,935 signatures, now closed - failed.
Stop all immigration and close the UK borders until ISIS is defeated.
463,500 signatures, now closed - failed.
Accept more asylum seekers and increase support for refugee migrants in the UK.
450,287 signatures, now closed - failed.
Consider a vote of No Confidence in Jeremy Hunt, Health Secretary
336,264 signatures - failed.
Make the production, sale and use of cannabis legal.
236,997 signatures, now closed - failed.
Stop spending a fixed 0.7 per cent slice of our national wealth on Foreign Aid
231,972 signatures - failed.
To debate a vote of no confidence in Health Secretary the Right Hon Jeremy Hunt
231,137 signatures, now closed - failed.
Vote no on military action in Syria against IS in response to the Paris attacks
227,744 signatures, now closed - failed.
STOP CAMERON spending British taxpayers money on Pro-EU Referendum leaflets
221,870 signatures, now closed - failed.
Stop allowing immigrants into the UK.
216,949 signatures, now closed - failed.
Vote no confidence in David Cameron
199,391 signatures, now closed - failed.
Make fair transitional state pension arrangements for 1950s women
193,186 signatures, now closed
No UK airstrikes on Syria.
190,223 signatures, now closed - failed.
No more school penalty fines and bring back the 10 day authorised absence
183,641 signatures
Hold a General Election in 2016
165,147 signatures
Keep the NHS Bursary
162,568 signatures, now closed - failed.
Introduce a tax on sugary drinks in the UK to improve our children's health.
155,516 signatures, now closed
Hold a public inquiry and a referendum over turning all schools into academies
155,360 signatures
Call on David Cameron to act to protect our steel industry & recall Parliament
153,352 signatures
Scrap plans to force state schools to become academies.
150,224 signatures
Make it illegal for a company to require women to wear high heels at work
144,880 signatures
Reverse the ESA disability benefit cut
135,018 signatures
Prevent the scrapping of the maintenance grant.
133,066 signatures, now closed
Stop retrospective changes to the student loans agreement
129,751 signatures