My thoughts so far.
I am really enjoying this game. Much like Mass Effect I notice a lot of flaws, and think that there is a lot they can do to improve it.
The camera is not too horrible once you get used to it, but it could be better.
The animation is not terrible, but it's not great.
With that said the game is very addictive. There's a lot to do in terms of character improvement, level up, complete a charm, find new loot. Get to the next level to equip loot found two levels ago, find a rune to insert into a level 1 charm to complete a level 2 charm, etc...
This, I think, is what makes the game work.
At this point I have a:
lvl 41 champion (21 hours or so)
lvl 16 Berserker (3+ hours in one sitting)
lvl 14 Defender (3 hours or so)
and
lvl 11 BioEngineer (slightly less than 2 hours I think).
The game certainly has its detractors, and I can understand some of their points, but for me the game is fun, and much like mass effect I find myself putting in a lot of time quickly for it. I'm hoping that the sales are sufficient for a sequel, although I think they will be. Also I would imagine that the cost of a sequel would be a lot lower as they have a solid foundation to build upon which should save them money as well as time.