Carl Paladino, a co-chair of President-elect Donald Trump's New York campaign, is facing a backlash over crude remarks about Barack and Michelle Obama.
Asked by a newspaper what he would most like to happen in 2017, Mr Paladino said he hoped President Obama would die from mad cow disease and the first lady would "return to being a male".
He later said his remarks were meant to be humorous.
But New York Governor Andrew Cuomo said the comments were "racist" and "ugly".
Many Twitter users also condemned Mr Paladino, with one saying there was "something deeply, horribly wrong" with him.
Meanwhile, the Parent Teacher Organisation in the city of Buffalo called on Mr Paladino to resign from its school board.