"Vegetarian Gene" appears to have evolved in human populations

Status
Not open for further replies.

kirblar

Member
There's also a seafood version! http://news.cornell.edu/stories/2016/03/eating-green-could-be-your-genes

Really interesting implications for tailoring ideal diets to people.

Cornell researchers describe a genetic variation that has evolved in populations that have historically favored vegetarian diets, such as in India, Africa and parts of East Asia.

A different version of this gene (called an allele) adapted to a marine diet was discovered among the Inuit in Greenland, who mainly consume seafood.

The vegetarian allele evolved in populations that have eaten a plant-based diet over hundreds of generations. The adaptation allows these people to efficiently process omega-3 and omega-6 fatty acids and convert them into compounds essential for early brain development and controlling inflammation. In populations that live on plant-based diets, this genetic variation provided an advantage and was positively selected in those groups.

In Inuit populations of Greenland, the researchers uncovered that a previously identified adaptation is opposite to the one found in long-standing vegetarian populations: While the vegetarian allele has an insertion of 22 bases (a base is a building block of DNA) within the gene, this insertion was found to be deleted in the seafood allele.

“The opposite allele is likely driving adaptation in Inuit,” said Kaixiong Ye, co-lead author of the paper appearing March 29 in the journal Molecular Biology and Evolution. Ye is a postdoctoral researcher in the lab of Alon Keinan, associate professor of biological statistics and computational biology, and the paper’s co-senior author.

“Our study is the first to connect an insertion allele with vegetarian diets, and the deletion allele with a marine diet,” Ye said.
Ye, Keinan and colleagues analyzed frequencies of the vegetarian allele in 234 primarily vegetarian Indians and 311 U.S. individuals and found the vegetarian allele in 68 percent of the Indians and in just 18 percent of Americans. Analysis using data from the 1,000 Genomes Project similarly found the vegetarian allele in 70 percent of South Asians, 53 percent of Africans, 29 percent of East Asians and 17 percent of Europeans.

“Northern Europeans have a long history of drinking milk and they absorbed enough end products from milk for long-chain fatty acid metabolism so they don’t have to increase capacity to synthesize those fatty acids from precursors,” said Ye.

“One implication from our study is that we can use this genomic information to try to tailor our diet so it is matched to our genome, which is called personalized nutrition,” he added.
 
Status
Not open for further replies.
Top Bottom