That makes me think of a game like Fallout - where gender isn't thrust upon the characters involved, how does that change some Gaffers perspective on the matter? From what I can tell, Anita still criticizes games like fallout, but I think she is against the idea of prostitutes in games, thus all instances of them are bad - and because she is a feminist her focus is on the females (I'm sure if pressed she'd be against male prostitutes in fallout too).
But how does GAF feel - should there not be prostitutes at all in games? Or 'gritty' elements like an underground sex-trade or sexually charged violence?
In her video Anita doesn't say that she is against the idea of prostitutes in games, but is against the way they are used as a game mechanic.
Here's a few points that would allow a game to be more realistic on that side:
1) first of all, prostitutes exist, but they are real human beings, while in games they are mostly based on the way prostitutes are depicted in other media, like movies and comics: there's no depth in their characters, there's no line of text that is not about using her as a sexual object, there's nothing that suggests that they don't like their condition, that maybe they are forced to do it with the threat of violence, that they are unhappy or that they still have a life beyond the "job": game writers simply use token characters to depict something that should be treated with more respect;
2) don't reward players with actual perks for having sex with a prostitute: there should be a loss on the main character's side for taking advantage of a prostitute, if possible not only a economic loss, but also in "reputation" or something: make other characters treat you differently if you frequently engage in sex with prostitutes;
3) if you commit violent acts against prostitutes in the game (I mean you the player, not the character, because the character does what the player wants it to do) there should be actual real deep consequences: if the character is caught by police, it's game over, you go back to before the murder or violence and think about what you're doing; even if there's no police involved, the main character should gradually be treated differently by other characters, to the point that if the character constantly practices violence on prostitutes just for fun, then other female (or male) characters actually become hostile to the main character in a sort of Dark Souls fashion, and that's for the entirety of the game: you had fun by acting like a monster? Well, you're going to suffer consequences.
Actual, real consequences in-game, that's what these "simulators" lack. I'm not talking about consequences for engaging in perilous activities like extreme sports or something: if for a round of motocross your character ends up with a broken leg for the rest of the game, than the game wouldn't be that fun. But it's a completely different matter when it comes to treating women characters as sexual object that can be used as vending machines and then thrown away: Anita explained all this perfectly in the video so I'm not going to repeat all her arguments, but that's the main point.