Ok, yeah DSR is the way to go in this game. FXAA at 1.78x or 2x DSR gets rid of almost all the jaggies and creates a smooth detailed image. Hell, even with no FXAA or MSAA, just downsampling seems to get rid of 90%+ of the jaggies, far more than MSAA 4x does at 1080p.
Running at 2650 x 1600 with no AA, reflections down to high, reflection MSAA off, tessellation down to high, particles and post fx down to high, soft shadows on softest, but with long shadows and high res shadows set to on; I seem to get fairly constant 60fps even with police chases through the city and lots of destruction. Might mess with the settings more, but I think this might be my go to settings for now.