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The latest figure for monthly active League of Legends players worldwide is in, and its a big one. Riot Games estimates over 100 million players actively play each month, as co-founders Marc Tryndamere Merrill and Brandon Ryze Beck told Polygons Phil Kollar in an exclusive interview this week.
The most recent figure available, from a few years ago, was an estimated 67 million monthly players. For comparison, competitor Valve announced in June that Dota 2 has over 13 million monthly unique players.
Source: http://www.riftherald.com/2016/9/13/12865314/monthly-lol-players-2016-active-worldwide
Kollar's Interview with Riot co-founders: http://www.polygon.com/2016/9/13/12...future-of-league-of-legends-studio-riot-games