One's on the nature of man, the other on the origin. Both important.
But Blade Runner barely even plumbs the depths of its theme. It's about an uninteresting detective chasing robots with no real personality. Yes, Roy wants to live, but that and murdering are ALL HE DOES the whole movie. There's never the sense that he's a person of depth and/or consequence, something to make his quest for self-preservation meaningful, and when he finally dies, he utters a fairly banal line that is followed by a fuckin' BIRD flying away, not only an egregious cliche but completely forced, given the aforementioned banality of the previous line. The love interest who is unaware of being a machine is kind of interesting in concept, but A) she's not a particularly deep nor interesting character, and B) they really only probe the fairly predictable "Well, how does ANY of us know the nature of our existence?" angle.
As I say, beautiful-looking movie, but the actual underlying story is pretty damn thin.
Edit: And I'd say that artistic quality carries greater value than historic import. A particular poem may or may not have made a splash in its time, but its ability to touch, to provoke, will remain.
Kraftwerk: It may be just a matter of opinion, but not all opinions are of equal weight; by necessity, one MUST be more right than another, if they are contradictory. Dialectic exists to scrutinize an to determine exactly which opinion that is, else what's the point of discussing anything? If it's all just a matter of subjectivity, I wouldn't even come in this thread, since you can't really debate a feeling or a personal reaction. You CAN debate quality.
Double Edit: And I'm sorry, but Blade Runner's not even in the same artistic galaxy as 2001, which fires on all cylinders: narrative, visual, auditory, and that ineffable "something" that separates great art from great craft. One can prefer Blade Runner for any NUMBER of reasons, for as I said, you can't really argue personal preference, but in terms of depth and complexity, 2001 blows it out of the water on just about every count.