It's only fair if you buy into the conceit that the game extends onto gamefaqs.
Nope. Entire first run was without looking shit up. I missed some items that would have made some parts easier I looked up in later runs, but I never really got frustrated with the game on it's own. I ended up summoning for ores and smores, on my first run, but that's why summoning is there.
I can't imagine one thing in the game that is just game breakingly hard that you need to look up. My goal in my first run was to search every nook and cranny, see what items do and whatnot.