The problem with all of these interviews is that they show that these people don't get what's wrong with the show. Yes, it ought to be more serialized, but the problem with the show isn't that it's too episodic (though that's handled clumsily) - the X-Files was plenty episodic and was still brilliant. The issue is that the characters are boring and each individual episode is poorly written and unentertaining. Having a boring episode of TV turn out to lead into a later plot development doesn't make it into a good episode, and these writers fundamentally don't seem to understand that.
Yeah, the characters are very weak and the attempts at building their backstories are clumsy and hamfisted. They are too one-dimensional, so whatever about their past you are meant to care about just isn't very interesting because the characters are so uninteresting.
The Scooby Gang flying to each McGuffin of the week is also poorly done, and wrapped up too cleanly too easily. They just seem like a bunch of amateurs getting lucky each time, not a crack team. The pilot episode didn't even establish what they were needed for, or especially why them. Skye being invited in just because set it up from the start as very unbelievable and her character annoying in a 'why are you there!' way. It's been badly written from the start.
There is just no weight to anything, and presumedly can't be or S.H.I.E.L.D. proper would be dealing with it. Leaving a very flawed, and dated, concept that they expected to coast along because er, Marvel I guess. Nothing they say about the show gives much hope they know what is wrong with it or what to do with it.