Wait, when you guys talk about Titan in the Marvel Universe, is it Saturn's Titan? Because if so they would be well inspired to move Thanos' home planet to somewhere else in the galaxy, being how much we now know about the satellite. It could have been good enough for sloppy scifi from the 60s, but aliens from Titan will be laughed at in 2015. It's the same reason we don't have Martians in our fictions any more.
Actually there are still plenty of things from Mars and the moon for that matter in comics and sci fi.
Real world really has no ramifications when you have had people building bases on these places for many years now and various other things.