I first read the book with basically no knowledge of mythology beyond really basic, so most of the hints for everything few over my head. At most, I'd catch the odd name or two and go "I heard that before! Somewhere!" But I didn't see Mr. Wednesdays true identity coming.
If I can make it through the book with basic understanding of whats going on despite that, anyone can.
The poster above is suggesting it's easy to guess Wed's identify
And the show so far is way more confusing and weirdly paced than the book (not least because the book's narrative works without all the politics, while the show is entirely about those politics, it seems)