I feel like a few people here are just instinctively reacting negatively to the presence of references in Osomatsu-san's first episode without actually considering the context. This isn't like most reference humor, where a reference is just thrown in at random in an otherwise unrelated context just to appeal to people who can recognize it. The concept the first episode is based on - the struggle of a decades-old property to figure out how they can still find an audience in modern times after an unexpected revival - it's a concept that could only work in this situation, the beginning of a new TV show in an old property. I'm a fan of narrative concepts that only work in a particular narrative format, as well as meta-narrative, and that is what we have here. It examines concepts such as the impossibility of staying true to yourself while chasing after popular trends of the day in a quest for popularity, the gap between generational expectations, and the difficulty of modernizing old franchises while retaining their unique appeal, all in the framework of a light-hearted and silly comedic take on the absurdities contained in present-day anime, specifically the most popular kind of anime right now - fujoshi/otome anime. (Remember that UtaPri is the best-selling TV anime this year, and it's not even close.) Much of that segment isn't even specific references, but a more generalized take on the otome concept. I really do see the first episode of Osomatsu-san as a brilliant, unique, and creative concept and execution, taking the meta-humor that the director and writer brought to their adaptation of Gintama to new heights.