I usually say "I really enjoy/love your work on ____________". Not much more to say other than that before you ask for their signature/sketch/picture/whathaveyou.
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Sex Criminals, Volume 1: One Weird Trick
Collecting issues #1-5 of Sex Criminals, One Weird Trick is a very fun read. I had only picked up the first issue and decided I could trade wait because Image is quick and dirty like that. And man, this is good stuff. As I finish one chapter, it keeps pulling me back in for more. While I was reading it, I prompted my significant other to give this a shot. She asked what it's about and I tell her it's about a girl who stops time...by having an orgasm. There was this awkward silence between us because she didn't know how to react. I continued to read and she continued to pretend she wasn't interested. But I know damn well she's going to read it when I'm not around. And you should too. :]
Of course, I can't post many images from the book because most panels are NSFW. So here's what I can show you.
Oh, and there's this scene where Suzie, protagonist of the series, flashes back to her high school days where another girl teaches her everything she knows about sex. Well, mostly sex positions. But she scribbles them on the bathroom walls to give a visual to Suzie. It looks like Matt Fraction and Chip Zdarsky list out a number of positions that didn't make it during that scene...
I can only imagine what the illustrations would look like. XD