I run this with an overclocked 7850 (to 7870 levels) 2 GB card on very high everything 1080P, with some settings set to high, get 40-50 FPS.
It is a very pretty game. But so was crysis 1 and 2. Graphically I think we're at the point of saturation and diminishing returns. As impressive as this game is, Uncharted still probably wows me more in terms of design.
Game itself is decent. I still feel Crysis 1 is where it's at.
Uncharted is a technical marvel, but the gameplay in that series is average at best. The shooting mechanics are weak, the platforming an afterthought, and the puzzles insultingly simple. Nice to show off an HDTV with in 2009, though.