It's already been mentioned in here, but the save system is horrendous. Otherwise I'm loving the game, but it is not fun in any way whatsoever to lose an hour or two of progress because the game decides to autosave inventory but not progress. This is the worst when doing side missions, which generally don't save at any point during the start, middle, or even ending of the mission.
I somehow managed to play for 1.5 hours last night without hitting an autosave. And then unwittingly walked into a really difficult action sequence, also without hitting any autosave. After dying and replaying the sequence several times, I finally decided my brain was too sleep deprived by then to get through it, so I just left my PS3 on overnight and went to bed. I haven't had to leave a console on like this since the Sega Genesis era. What terrible design.
What kills me is that the game checkpoints constantly, but doesn't actually commit those checkpoints to the save file. It just arbitrarily forces long play sessions because if you quit or power cycle you lose the checkpoint.
