GTX 570 (factory OC'd).
There's one specific area of the game that is completely bugged. Every second I spend there is a gamble as to whether or not the game will crash. If I'm lucky, the crash will simply be the game freezing then booting back to Windows, reporting an error. If I'm unlucky the screen fills with green graphical artifacts while the game freezes, then the image is lost completely and my screen reports no signal from the GPU, forcing me to restart the computer. Or, if I'm really lucky, I can get in and out without the game freezing at all.
I'd blame my GPU, but nowhere else in the game have I had any graphical or performance issues (other than the common ones, eg: long loading), nor have I had any problem in any other game.
Thus I am blaming the game, and I'm pretty fucking livid.