Early resistances offer a very large % buff so you get them whenever you can fit them.
Can easily go from 1 to two hits or even 2 to 3 smaller hits.
Good amount of VIT, 10 dsc is very good, +50 is a high res all number, 3 sockets is beast.
I'd sooner make a build that never gets hit, and does 100k damage on critical hits. Going from one to two hits doesn't mean a lot when things like Tongue Lashers gang up on you, or the phasing enemies/rakanoth (who's really one hit in any case, who are we kidding)/vipers/etc.
The key to playing an Inferno DH has been risk mitigation for me. Aggroing things one or two at a time and getting them lined up in a row. Slowing them with caltrops, and then dumping my hatred as fast as I possibly can. The thought of trying to make a build around the idea that I'd ever get hit is...ehh..
(I should mention that I don't even have close to the gold needed for that 100k damage build. I'm getting there though...when these exalted grand crag hammer plans finally sell. Currently at 1.5m, hoping for 2)